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ea0081p671 | Pituitary and Neuroendocrinology | ECE2022

Targeting invasive pituitary adenomas: in vitro studies and in vivo investigations in a murine model of invasive pituitary tumors obtained by orthotopic pituitary GC cells injection

Chasseloup Fanny , Lefevre Etienne , Dormoy Alexandre , Ladurelle Nataly , Mignot Tiphaine , Janot Clement , Hage Mirella , Viengchareun Say , Zizzari Philippe , Chanson Philippe , Buchfelder Michael , Kamenicky Peter

Context: Surgical removal is the primary treatment option for pituitary adenomas. However, pituitary surgery is frequently incomplete because of invasion of extrasellar cerebral structures, notably, of the cavernous sinus. Our objective was to study the molecular basis of the cavernous sinus invasion by pituitary adenomas.Methods: We analyzed a tissue collection of 19 invasive pituitary adenomas with a sample from the intrasellar portion and a sample fro...

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Targeting invasive pituitary adenomas: in vitro studies and in vivo investigations in a murine model of invasive pituitary tumors obtained by orthotopic pituitary GC cells injection

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